BDBM50084948 CHEMBL195515::GW7604

SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(\C=C\C(O)=O)cc1)c1ccccc1

InChI Key InChIKey=SCVIEONTACSLJA-UHFFFAOYSA-N

Data  3 KI  19 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50084948   

LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of hERG channel by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 154nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation measured after 21 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 238nMAssay Description:Antagonist activity at ERalpha (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation measured after 21 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 3.80nMAssay Description:Displacement of fluorescent-labelled E2 from recombinant human GST-tagged ERbeta by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 5.40nMAssay Description:Displacement of fluorescent-labelled E2 from recombinant human GST-tagged ERalpha by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 43nMAssay Description:Inhibition of Fluormone-ES2 binding affinity to ERalpha (unknown origin) after 2 hrs by fluorescent polarization based competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataEC50:  1.70nMAssay Description:Induction of ERalpha degradation in human MCF7 cells in phenol red free RPMI medium containing 5% charcoal-stripped FBS incubated for 4 hrs by IRDye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 1.30nMAssay Description:pIC50 for 1 nM estradiol-induced Ishikawa cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 7nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 18 to 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 242nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as inhibition of estrogen-induced transcription preincubated overnight followed by estrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 0.145nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 6.80nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 3.16E+4nMAssay Description:Agonist activity at progesterone receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataEC50:  1.70nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-beta (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-alpha (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 3.00E+4nMAssay Description:Agonist activity at ER alpha in human MCF7 cells assessed as PR gene expression after 24 hrs by laser scanning imaging cytometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at ER alpha in human MCF7 cells assessed as inhibition of estradiol-induced PR expression treated for 24 hrs after incubation wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 7nMAssay Description:Suppression of ER alpha in human MCF7 cells after 24 hrs by immunostaining analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataIC50: 0.150nMAssay Description:Binding affinity to ER alpha (unknown origin) by LanthaScreen TR-FRET competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataKi:  10nMAssay Description:Binding affinity for human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50084948(GW7604 | CHEMBL195515)
Affinity DataKi:  27nMAssay Description:Displacement of Fluormone ES2 from full-length recombinant ER alpha (unknown origin) assessed as inhibition constant incubated for 2 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed