BDBM22373 (3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine::GSK 8470::bicyclo[3.3.0]-oct-2-ene, 5a

SMILES [H][C@]12CCC[C@@]1(Nc1ccccc1)C(=C(C2)C(\CCC)=C\CCC)c1ccccc1

InChI Key InChIKey=WRZLRWJDJPFDGG-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22373   

TargetSteroidogenic factor 1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM22373(bicyclo[3.3.0]-oct-2-ene, 5a | (3aS,6aR)-5-[(4E)-o...)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNuclear receptor subfamily 5 group A member 2(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM22373(bicyclo[3.3.0]-oct-2-ene, 5a | (3aS,6aR)-5-[(4E)-o...)
Affinity DataEC50:  631nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNuclear receptor subfamily 5 group A member 2(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM22373(bicyclo[3.3.0]-oct-2-ene, 5a | (3aS,6aR)-5-[(4E)-o...)
Affinity DataEC50:  430nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed
TargetSteroidogenic factor 1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM22373(bicyclo[3.3.0]-oct-2-ene, 5a | (3aS,6aR)-5-[(4E)-o...)
Affinity DataEC50:  54nMAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2008
Entry Details Article
PubMed