BDBM50563816 Eleclazine::GS-6615

SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc2OCCN(Cc3ncccn3)C(=O)c2c1

InChI Key InChIKey=YNUAEEJQYHYLMS-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50563816   

TargetSodium channel protein type 2 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NaV1.2 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ERG expressed stably in CHO cells by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 3 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 260nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 1 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 0.1 Hz frequency by manual patch clamp techniqu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of NaV1.8 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NaV1.7 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of NaV1.4 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of NaV1.1 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of NaV1.8 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NaV1.7 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of NaV1.6 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of NaV1.4 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of NaV1.2 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of NaV1.1 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -80 mV resting membrane potential by electrophy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -120 mV resting membrane potential by electroph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of NaV1.6 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed