BDBM50521720 GS-5816::Velpatasvir

SMILES [H][C@@]1(COC)CN(C(=O)[C@H](NC(=O)OC)c2ccccc2)[C@@]([H])(C1)c1nc(c[nH]1)-c1ccc-2c(COc3cc4c5[nH]c(nc5ccc4cc-23)[C@]2([H])CC[C@]([H])(C)N2C(=O)[C@@H](NC(=O)OC)C(C)C)c1

InChI Key InChIKey=FHCUMDQMBHQXKK-UHFFFAOYSA-N

Data  32 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50521720   

TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0130nMAssay Description:Inhibition of NS5A in wild type HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV wild type genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.130nMAssay Description:Inhibition of NS5A in HCV genotype 6e D88 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.210nMAssay Description:Inhibition of NS5A A30K mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0160nMAssay Description:Inhibition of NS5A in wild type HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0310nMAssay Description:Inhibition of NS5A Q30R mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in wild type HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  8.5nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in HCV genotype 6a HK6 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A P58S mutant in HCV genotype 2b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0160nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0110nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0110nMAssay Description:Inhibition of NS5A R44K mutant in HCV genotype 2b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in wild type HCV genotype 2b AY232738 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A N62S mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A N62V mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.25nMAssay Description:Inhibition of NS5A Q30E mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0530nMAssay Description:Inhibition of NS5A Y93C mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.220nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0320nMAssay Description:Inhibition of NS5A Q30H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.105nMAssay Description:Inhibition of NS5A M28T mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0140nMAssay Description:Inhibition of NS5A in wild type HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0160nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a J6 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0540nMAssay Description:Inhibition of NS5A in HCV genotype 5a SA13 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0160nMAssay Description:Inhibition of NS5A in HCV genotype 2a J6 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.0140nMAssay Description:Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521720(GS-5816 | Velpatasvir)
Affinity DataEC50:  0.00500nMAssay Description:Inhibition of NS5A K44R mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed