BDBM50212258 GS-4997::Selonsertib
SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
InChI Key InChIKey=YIDDLAAKOYYGJG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50212258
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human full length recombinant ASK1 (654 to 971 residues) expressed in Sf21 cells using STK-substrate 3-biotin as substrate incubated fo...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of ASK1 in human HEK293 cells transfected with AP1 assessed as inhibition of AP1-induced firefly luciferase activity preincubated for 1 hr...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length recombinant ASK1 using STK-Substrate-3 biotin as substrate in presence of ATP measured after 2 hrs by HTRP kinase ass...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin) by competitive TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Inhibition of ASK1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ASK1 catalytic domain (654 to 971 residues) expressed in baculovirus infected sf21 cells using ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 6(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of ASK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK293T cells assessed as reduction in T848 autophosphorylation incubated for 1 hr by MSD assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate preincubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-b...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hrMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Human)
South China University
Curated by ChEMBL
South China University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin) using biotin-MBP as substrate after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair