BDBM86283 CAS_345-78-8::CAS_39069-52-8::GS 39783::N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine::NSC_5032::Pseudoephedrine,(+)

SMILES CSc1nc(c(c(n1)NC2CCCC2)[N+](=O)[O-])NC3CCCC3

InChI Key InChIKey=GSGVDKOCBKBMGG-UHFFFAOYSA-N

Data  4 KI  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 86283   

TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataEC50:  741nMAssay Description:Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataKi:  2.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataKi:  32.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataKi:  224nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataKi:  1.99E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed