BDBM50390992 CHEMBL601773::GNF-Pf-3462

SMILES CC(C)[C@@]1(NC(=O)[C@@H]2C[C@H]3[C@@H](Cc4c[nH]c5cccc3c45)N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O

InChI Key InChIKey=DEQITUUQPICUMR-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50390992   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human beta 2 adrenergic receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataKi:  1.60E+4nMAssay Description:TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataKi:  5.11E+5nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataKi:  1.67E+5nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataKi:  1.12E+5nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed