BDBM50238837 CHEMBL581893::GNF-Pf-3346

SMILES COc1ccc2c(C)nc(NC(N)=N)nc2c1

InChI Key InChIKey=ZJBMSSBTCGJZEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50238837   

TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL
LigandPNGBDBM50238837(GNF-Pf-3346 | CHEMBL581893)
Affinity DataIC50: 9.31E+4nMAssay Description:Inhibition of MPO in human neutrophils assessed as reduction in HOCl production preincubated for 30 mins followed by H2O2 addition by APF staining ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoperoxidase(Bovine)
Free University of Brussels

Curated by ChEMBL
LigandPNGBDBM50238837(GNF-Pf-3346 | CHEMBL581893)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL
LigandPNGBDBM50238837(GNF-Pf-3346 | CHEMBL581893)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyeloperoxidase(Human)
Free University of Brussels

Curated by ChEMBL
LigandPNGBDBM50238837(GNF-Pf-3346 | CHEMBL581893)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed