BDBM50196122 CHEMBL217366::GNF-PF-3878::N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine::TCMDC-124255

SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1

InChI Key InChIKey=CUVBGWMAORETGV-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50196122   

TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50196122(N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21(DE3) strain using H3K4me2 peptide as substrate incubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Timisoara of The Romanian Academy

Curated by ChEMBL
LigandPNGBDBM50196122(N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine...)
Affinity DataKi:  37.0nMAssay Description:Binding affinity to human cloned Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Timisoara of The Romanian Academy

Curated by ChEMBL
LigandPNGBDBM50196122(N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Juvantia Pharma

Curated by ChEMBL
LigandPNGBDBM50196122(N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Juvantia Pharma

Curated by ChEMBL
LigandPNGBDBM50196122(N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine...)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed