BDBM50240374 3-(4-biphenylylcarbonyl)propionic acid::3-(4-phenylbenzoyl)propionic acid::4-(4-biphenylyl)-4-oxobutyric acid::4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid::4-biphenyl-4-yl-4-oxobutanoic acid::CHEMBL277522::Fenbufen::gamma-oxo(1,1'-biphenyl)-4-butanoic acid

SMILES OC(=O)CCC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=ZPAKPRAICRBAOD-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240374   

TargetCaspase-1(Human)
University of Colorado

LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 4.40E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-3(Human)
University of Colorado

LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 1.20E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
University of Colorado

LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 570nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-5(Human)
University of Colorado

LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 870nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-9(Human)
University of Colorado

LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 760nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme-immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataKi:  3.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed