BDBM50085044 (S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid::(S)-2-(2-benzoylphenylamino)-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid::2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID::2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid(GI 262570)::CHEMBL107367::Farglitazar
SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
InChI Key InChIKey=ZZCHHVUQYRMYLW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 50085044
Affinity DataEC50: 1.40nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PBP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of CBP1-453 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 450nMAssay Description:Binding affinity to human Peroxisome proliferator activated receptor alpha using scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 345nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+3nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.339nMAssay Description:Transactivation of PPARgamma assessed as induction of alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 122nMAssay Description:Transactivation of human Gal4-fused PPARalpha LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.339nMAssay Description:Tested functionally in vitro for inducing 50% of the maximum alkaline phosphate activity (Transactivation) against Peroxisome proliferator activated ...More data for this Ligand-Target Pair
Affinity DataEC50: 457nMAssay Description:In vitro transactivation of Peroxisome proliferator activated receptor alpha.More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferat...More data for this Ligand-Target Pair
Affinity DataEC50: 0.339nMAssay Description:in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:-log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 0.339nMAssay Description:Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 457nMAssay Description:Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 450nMAssay Description:Agonist activity for Human PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.340nMAssay Description:Maximal reporter activity against human Peroxisome proliferator activated receptor gamma Gal4 chimeric in transiently transfected CV-1 cells by funct...More data for this Ligand-Target Pair
Affinity DataEC50: 457nMAssay Description:Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against human Peroxisome pr...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferat...More data for this Ligand-Target Pair
Affinity DataEC50: 0.340nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 0.350nMAssay Description:Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against murine Peroxisome p...More data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of Src-1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.340nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataEC50: 0.350nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 217nMAssay Description:Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 321nMAssay Description:Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.87E+3nMAssay Description:Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
Affinity DataKi: 490nMAssay Description:Binding affinity to human Peroxisome proliferator activated receptor alpha using scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 490nMAssay Description:Tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Binding affinity to bind to human Peroxisome proliferator activated receptor delta using scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.07E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor deltaMore data for this Ligand-Target Pair
Affinity DataKi: 6.31E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1.11E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair