BDBM50206215 7,8-Dihydroxy-6-methoxy-chromen-2-one::7,8-dihydroxy-6-methoxy-2H-chromen-2-one::CHEMBL54909::FRAXETIN

SMILES COc1cc2ccc(=O)oc2c(O)c1O

InChI Key InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N

Data  7 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50206215   

TargetProstaglandin G/H synthase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataIC50: 5.24E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataIC50: 3.21E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  610nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  4.32E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  4.86E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  5.51E+3nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  7.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  9.73E+3nMAssay Description:Inhibition of human carbonic anhydrase 13 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206215(CHEMBL54909 | 7,8-dihydroxy-6-methoxy-2H-chromen-2...)
Affinity DataKi:  9.43E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed