BDBM50112347 CHEMBL3609327::FRAX597

SMILES CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O

InChI Key InChIKey=DHUJCQOUWQMVCG-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50112347   

TargetSerine/threonine-protein kinase PAK 1 [249-545,K299R](Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 12.8nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19.3nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant human PAK1 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PAK4 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human PAK3 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PAK2 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 88nMAssay Description:Inhibition of PAK1 phosphorylation in human MCF10A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 23nMAssay Description:Inhibition of PAK3 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 23nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)