BDBM50399540 FORETINIB::US10464902, Foretinib::US10882853, Compound For-Oxide
SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
InChI Key InChIKey=CXQHYVUVSFXTMY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 164 hits for monomerid = 50399540
Affinity DataIC50: 1.89nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 6.72nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataIC50: 5.61nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha [1-973](Human)
Shenyang Pharmaceutical University
Shenyang Pharmaceutical University
Affinity DataIC50: 6.78nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataIC50: 4.86nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataIC50: 2.99E+3nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataIC50: 3.52nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataIC50: 6.89nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
Affinity DataKd: 52nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu,Tyr)4:1 as substrate by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrateMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Korea University of Science and Technology
Curated by ChEMBL
Korea University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of ROS1 (unknown origin) expressed in mouse BA/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met kinase (unknown origin)More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKd: 0.200nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of Ron (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of c-Kit (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of FLT-3 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Met (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of KDR (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of RON (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of Flt-1 (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 1 h...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of Flt-4 (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of c-Met (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of AXL in lapatinib-sensitive human BT474 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human full length MET by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of c-Kit (unknown origin) using biotinylated-poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measur...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair