BDBM190178 BDBM50400783::EPZ004744::US10273223, Compound B-90::US9175331, 3::US9637472, Compound B-90
SMILES CC(C)n1ncc2c(cc(nc12)C1CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
InChI Key InChIKey=ZECOLGPOIRWPAH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 190178
Affinity DataIC50: 1.52E+3nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
Affinity DataIC50: 743nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
Affinity DataIC50: 113nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of [3H]-SAM from N-terminal FLAG-tev-tagged human EZH2 expressed in baculovirus infected insect cells by liquid scintillation counter me...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Competitive inhibition of human EZH2 using H3K27A as substrate in presence of SAMMore data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Non-competitive inhibition of human EZH2 using [3H]-SAM as substrate in presence of H3K27AMore data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of human FLAG-tev-fused EZH2 expressed in baculovirus infected Sf9 insect cells using H3K27 peptide as substrate in presence of [3H]-SAM b...More data for this Ligand-Target Pair