BDBM50235980 2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid::CHEMBL429876::CILENGITIDE::EMD-12192::EMD-121974::[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid::c(RGDfMeV)::cyclo(Arg-Gly-Asp-D-Phe-[N-Me]Val)
SMILES [#6]-[#6](-[#6])-[#6@@H]-1-[#7](-[#6])-[#6](=O)-[#6@@H](-[#6]-c2ccccc2)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O
InChI Key InChIKey=LJKWPNDKPDWWIA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 51 hits for monomerid = 50235980
Affinity DataIC50: 15nMAssay Description:Inhibition of human fibronectin binding to human integrin alpha5beta1 incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of fibronectin binding to human Integrin alpha5beta1 receptor by competitive ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]Echistatin from human placental integrin alpha-V-beta-5 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor by solid phase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Displacement of [125I]echistatin from human placental integrin alphaVbeta3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Displacement of [125I]-echistatin from alphavbeta3 integrin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of vitronectin binding to human alphaVbeta3 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of fibronectin binding to soluble alpha5beta1 integrin (unknown origin) after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at alpha5beta1 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Displacement of biotinylated ECM from human placental integrin alphavbeta3 receptor incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human vitronectin binding to human integrin alphavbeta3 receptor after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of vitronectin binding to Integrin alphaVbeta3 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Binding affinity to alphaVbeta3 integrin in human SKOV3 cells assessed as inhibition of cell adhesion to fibrinogen measured after 2 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of vitronectin binding to recombinant human integrin alphaV (Phe31 to Val992 residues) beta3 (Gly27 to Asp718 residues) expressed in CHO c...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of vitronectin binding to recombinant human integrin alphaV (Phe31 to Val992 residues) beta5 (Gly24 to Asn719 residues) expressed in CHO c...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of fibronectin binding to recombinant human integrin alpha5 (Phe42 to Tyr995 residues) beta1 (Gln21 to Asp728 residues) expressed in CHO c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Binding affinity to human integrin alphaVbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Binding affinity to human integrin alpha5beta1 incubated for 1 hr by ELISA based solid phase integrin binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human SK-OV-3 cells expressing alphavbeta5 integrin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human HEK293 cellsMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant integrin alphavbeta3 incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant integrin alpha5beta1 incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Displacement of [125I]echistatin from AlphaV-beta-3 integrin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of vitronectin binding to human alphavbeta3 integrin receptor after 1 hr by competitive solid-phase binding ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of fibronectin binding to human alpha5beta1 integrin receptor after 1 hr by competitive solid-phase binding ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of fibrinogen binding to alpha2bbeta3 integrin receptor (unknown origin) after 1 hr by competitive solid-phase binding ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Binding affinity to alpha5beta1 integrin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.06E+5nMAssay Description:Binding affinity to alpha2b/beta3 integrin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of vitronectin binding to human alphaVbeta3 integrin after 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of vitronectin binding to human alphaVbeta5 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of fibronectin binding to human alpha5beta1 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of fibrinogen binding to human alpha2b/beta3 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Binding affinity to alphaVbeta3 integrin (unknown origin)More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Binding affinity to alphaVbeta5 integrin (unknown origin)More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]echistatin from AlphaV-beta-5 integrin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.860nMAssay Description:Binding affinity to Integrin alpha-v-beta-3 receptor by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to integrin alphav/beta3 heterodimer in human M21 cells assessed as inhibition of integrin-mediated human M21 cell adhesion to vitro...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]-echistatin from alpha-v-beta-5 integrin receptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-5 receptor by solid phase assayMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to Integrin alpha-v-beta-5 receptor by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Binding affinity to soluble truncated human recombinant Fc-tagged alphaVbeta3 and integrins were expressed in HEK293T cells after 2 hrs by competitio...More data for this Ligand-Target Pair
Affinity DataIC50: 4.21E+3nMAssay Description:Inhibition of fibrinogen binding to Integrin alpha2bbeta3 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of latency-associated peptide binding to Integrin alphaVbeta6 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Human)
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Department of Organic Chemistry Ugo Schiff University of Firenze Via Della Lastruccia 13
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of vitronectin binding to Integrin alphaVbeta5 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair