BDBM50305261 CHEMBL589390::Dimebolin

SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1

InChI Key InChIKey=JNODQFNWMXFMEV-UHFFFAOYSA-N

Data  9 KI  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50305261   

TargetCholinesterase(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 8.24E+4nMAssay Description:Displacement of [3H]ifenprodyl from NMDA receptor NR2B subunit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 5.67E+4nMAssay Description:Inhibition of phosphotidylserine liposome-stimulated Dynamin 1 (unknown origin) GTPase activity by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 7.90E+6nMAssay Description:Inhibition of BuChE (unknown origin) assessed as decrease in thiocholine accumulation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataEC50:  2.50E+7nMAssay Description:Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 1.36E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 1.58E+3nMAssay Description:Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 890nMAssay Description:Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 890nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 158nMAssay Description:Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 1.58E+3nMAssay Description:Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 1.16E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced increase in intracellula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5HT7 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  26nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  26nMAssay Description:Binding affinity to human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  34nMAssay Description:Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  34nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  76nMAssay Description:Binding affinity to 5HT2C receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi: >100nMAssay Description:Binding affinity to 5HT1A receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  119nMAssay Description:Binding affinity to rat recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed