BDBM50079527 (3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine::CHEMBL101740::DOXEPIN::cis-doxepin

SMILES CN(C)CC\C=C1\c2ccccc2COc2ccccc12

InChI Key InChIKey=ODQWQRRAPPTVAG-UHFFFAOYSA-N

Data  33 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50079527   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 0.00300nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 0.0100nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.178nMAssay Description:Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.280nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.490nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 expressed in CHO-K1 cells membrane incubated for 1 hr by microbeta liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  8.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  23.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  26nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  27nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  29.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  52nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  68nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  75nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  82nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H4 receptor(Human)
The Centre For Addiction and Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  106nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  126nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  126nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
National Institute of Neurological Disorders and Stroke

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  136nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  201nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  276nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  360nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  710nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi:  1.27E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079527(CHEMBL101740 | cis-doxepin | DOXEPIN | (3E)-3-dibe...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed