BDBM81965 1-(4-ethyl-2,5-dimethoxyphenyl)propan-2-amine::CAS_62066::CHEMBL8224::DOET,(-)::NSC_62066::doet

SMILES CCc1cc(OC)c(CC(C)N)cc1OC

InChI Key InChIKey=HXJKWPGVENNMCC-UHFFFAOYSA-N

Data  51 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 53 hits for monomerid = 81965   

Target5-hydroxytryptamine receptor 2C(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataEC50:  9.18nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataEC50:  2.40nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  0.540nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  14.4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  27.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  28.8nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Bovine)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  100nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  100nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  100nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor of rat frontal cortex using [3H]ketanserin radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  101nMAssay Description:Compound was tested for binding affinity towards 5-HT1C (5-HT1C) receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  107nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  574nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  1.23E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  1.28E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  1.45E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  2.20E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  2.80E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  3.55E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  4.57E+3nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  5.72E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  6.62E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  9.56E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi:  9.78E+3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H2 receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCannabinoid receptor 2(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetHistamine H4 receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetCarnitine O-palmitoyltransferase 2, mitochondrial(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetNischarin(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Oklahoma

LigandPNGBDBM81965(CHEMBL8224 | 1-(4-ethyl-2,5-dimethoxyphenyl)propan...)
Affinity DataKi: >1.00E+4nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
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