BDBM50005257 (+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::(+)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::(+/-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::(-)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::(-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine::2-(2-Methoxy-phenyl)-1-methyl-ethylamine::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((-)-DOB)::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((R)-(-)-DOB)::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((S)-(+)-DOB)::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine(DOB)::2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine[R(-)DOB]::2-(5-Bromo-2,4-dimethoxy-phenyl)-1-methyl-ethylamine::Brolamfetamine::CHEMBL6607::DOB::Racemic DOB

SMILES COc1cc(CC(C)N)c(OC)cc1Br

InChI Key InChIKey=FXMWUTGUCAKGQL-UHFFFAOYSA-N

Data  102 KI  1 IC50  1 Kd  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 112 hits for monomerid = 50005257   

Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  72nMAssay Description:Ability to stimulate phosphoinositide hydrolysis in NIH3T3 cells expressing the 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  72nMAssay Description:Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  60nMAssay Description:Serotonin 5-HT2A receptor-mediated intracellular calcium [Ca2+] mobilization in rat A7r5 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Universidad De Chile

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at rat 5HT2A receptor expressed in mouse NIH3T3 cells assessed as stimulation of inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKd:  44.7nMAssay Description:Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  0.520nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  0.314nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  0.927nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataEC50:  0.246nMMore data for this Ligand-Target Pair
In DepthDetails

Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for 5-HT2A serotonin receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]DOI from recombinant human 5HT2A expressed in Syrian hamster AV12 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  0.790nMAssay Description:Affinity towards [3H]- DOB -labeled 5-hydroxytryptamine 2 receptor sites in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]DOB from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  1.17nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  1.51nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity at cloned rat 5-hydroxytryptamine 2A receptor using [3H]DOB as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.20nMAssay Description:In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.60nMAssay Description:Compound was evaluated for its ability to displace 0.25 nM [125I](R)-DOI from binding sites in rat frontal cortex.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity at cloned rat 5-hydroxytryptamine 2C receptor using [3H]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.80nMAssay Description:In vitro binding to 5-hydroxytryptamine 2C receptor using [125 I]-DOIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Cerebrus

Curated by PDSP Ki Database
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  2.88nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  3.01nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Cerebrus

Curated by PDSP Ki Database
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  3.90nMMore data for this Ligand-Target Pair
In DepthDetails

Target5-hydroxytryptamine receptor 1A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  6.10nMAssay Description:Binding affinity towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  6.31nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  7.76nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  21.8nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  22nMAssay Description:Binding affinity towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  23.1nMMore data for this Ligand-Target Pair
In DepthDetails

Target5-hydroxytryptamine receptor 2B(Human)
Cerebrus

Curated by PDSP Ki Database
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  26.9nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  32nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:The compound evaluated for its affinity against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor sites by using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor of rat frontal cortex using [3H]ketanserin radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Affinity towards [3H]- ketanserin-labeled 5-hydroxytryptamine 2 receptor sites in rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50005257(2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylami...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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