BDBM36355 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine::DMH2::US9040694, 2

SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12

InChI Key InChIKey=DXLXRNZCYAYUED-UHFFFAOYSA-N

Data  8 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 36355   

TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataEC50:  100nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataEC50: >5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataEC50:  2.50E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 42.8nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 1.58E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 3.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 2.42E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 42.8nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 1.58E+3nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase subunit beta-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 527nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 2.42E+3nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent