BDBM50000999 CHEBI:81724::DIMINAZENE

SMILES NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1

InChI Key InChIKey=XNYZHCFCZNMTFY-UHFFFAOYSA-N

Data  3 KI  3 IC50  1 EC50

PDB links: 11 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50000999   

TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50: 5.69E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 2(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of pH 5.5-stimulated mouse ASIC2a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 2(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50: 4.52E+4nMAssay Description:Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataEC50:  8.04E+3nMAssay Description:Activation of recombinant human ACE2 using McaAPK(Dnp)-OH as substrate preincubated for 15 mins followed by substrate addition spectra max Gemini M5 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmiloride-sensitive amine oxidase [copper-containing](Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataKi:  13nMAssay Description:Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDiamine acetyltransferase 1(Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human SSAT using spermidine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataKi:  5.42E+3nMAssay Description:Inhibition of furin (unknown origin) using Pyr-RTKR-MCA as substrate incubated for 30 mins and measured by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed