BDBM231661 DEt (12)::US10668094, Compound DEt

SMILES CCN1CCC(O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)C(CCC6C5C[C@H](O)[C@]5(C)[C@H](CC[C@]65O)C5=CC(=O)OC5)C4)O[C@H]3C)O[C@H]2C)OC(C)C1

InChI Key InChIKey=LCGZRYIGXYRVKQ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 231661   

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  14.4nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  16.4nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  18.5nMAssay Description:Inhibition of Na,K-ATPase activity of the detergent-soluble α1β1, α2β1, and α3β1 complexes by CGs was done exactly as d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  23.2nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  53nMAssay Description:Inhibition of Na,K-ATPase activity of the detergent-soluble α1β1, α2β1, and α3β1 complexes by CGs was done exactly as d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM231661(DEt (12) | US10668094, Compound DEt)
Affinity DataKi:  138nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In DepthDetails
US Patent