BDBM18958 (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)(ethyl)amine::CHEMBL1600::DEA::Deethylamiodarone::Desethylamiodarone::L 33520

SMILES CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCNCC)c(I)c1

InChI Key InChIKey=VXOKDLACQICQFA-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18958   

TargetThyroid hormone receptor alpha(Chicken)
University of Amsterdam

LigandPNGBDBM18958(DEA | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-...)
Affinity DataIC50: 4.70E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Rat)
University of Amsterdam

LigandPNGBDBM18958(DEA | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-...)
Affinity DataIC50: 2.70E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM18958(DEA | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-...)
Affinity DataEC50:  33nMAssay Description:Antagonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM18958(DEA | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-...)
Affinity DataIC50: 1.54E+4nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM18958(DEA | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-...)
Affinity DataIC50: 2.52E+4nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.025 uM) in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed