BDBM50396537 CHEMBL2171121::D3RKN_50

SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2ccccc2Cl)c2c(N)ncnc12

InChI Key InChIKey=OTGQMOPRPFKJKL-UHFFFAOYSA-N

Data  1 IC50  3 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50396537   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50396537(CHEMBL2171121 | D3RKN_50)Copy SMILESCopy InChI

Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetVascular endothelial growth factor receptor 2(Human)
D3R/Abbott

LigandBDBM50396537(CHEMBL2171121 | D3RKN_50)Copy SMILESCopy InChI

Affinity DataKd:  660nMAssay Description:D3R2021More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2023
Entry Details
Copy Entry DOID3R

Copy Rxn URL

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandBDBM50396537(CHEMBL2171121 | D3RKN_50)Copy SMILESCopy InChI

Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2023
Entry Details
Copy Entry DOID3R

Copy Rxn URL

TargetMitogen-activated protein kinase 14(Human)
D3R/Abbott

LigandBDBM50396537(CHEMBL2171121 | D3RKN_50)Copy SMILESCopy InChI

Affinity DataKd:  27nMAssay Description:D3R2023More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2023
Entry Details
Copy Entry DOID3R

Copy Rxn URL