BDBM12342 2H-chromen-2-one::CHEMBL6466::Coumarin
SMILES O=c1ccc2ccccc2o1
InChI Key InChIKey=ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 73 hits for monomerid = 12342
TargetUDP-glucuronosyltransferase 1A1(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology
Curated by ChEMBL
Dalian University of Technology
Curated by ChEMBL
Affinity DataIC50: 2.44E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo
Curated by ChEMBL
University of S£O Paulo
Curated by ChEMBL
Affinity DataIC50: 6.42E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo
Curated by ChEMBL
University of S£O Paulo
Curated by ChEMBL
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetGlyceraldehyde-3-phosphate dehydrogenase(Human)
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataIC50: 6.92E+5nMAssay Description:Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50More data for this Ligand-Target Pair
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibitory effect on monoamine oxidase A, SD on IC50 values < 10%More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory effect on Monoamine oxidase B, SD on IC50 values < 10%More data for this Ligand-Target Pair
TargetGlyceraldehyde-3-phosphate dehydrogenase, glycosomal(Trypanosoma cruzi)
Universidade De S£O Paulo
Curated by ChEMBL
Universidade De S£O Paulo
Curated by ChEMBL
Affinity DataIC50: 6.92E+5nMAssay Description:Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B10(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A4(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1-6(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B7(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human CA1 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.30E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology
Curated by ChEMBL
Dalian University of Technology
Curated by ChEMBL
Affinity DataKi: 4.06E+3nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataKi: 5.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.60E+3nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.90E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of full length human recombinant CA2 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human CA2 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.30E+3nM ΔG°: -6.86kcal/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
Affinity DataKi: 9.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.96E+4nMAssay Description:Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.23E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair