BDBM50040237 2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine::2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine(clothiapine)::2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine::CHEMBL304902::Clothiapine

SMILES CN1CCN(CC1)C1=Nc2ccccc2Sc2ccc(Cl)cc12

InChI Key InChIKey=KAAZGXDPUNNEFN-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50040237   

TargetD(2) dopamine receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  0.490nMAssay Description:The ability of test compounds to displace 3H-raclopride at the D2s receptor can be determined on membranes from D2s-transfected CHO cells (Bmax 13 pm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
Go to US Patent

TargetSerotonin 2 (5-HT2) receptor(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  4.40nMAssay Description:In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  14nMAssay Description:Binding affinity against dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50040237(2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1...)
Affinity DataKi:  136nMAssay Description:In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed