BDBM50074629 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imidazole::CHEMBL278462::Cipralisant

SMILES CC(C)(C)CCC#C[C@@H]1C[C@H]1c1cnc[nH]1

InChI Key InChIKey=CVKJAXCQPFOAIN-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50074629   

TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Gliatech

Curated by ChEMBL
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]Nalpha-methylhistamine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Gliatech

Curated by ChEMBL
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.120nMAssay Description:In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolarization-induced release of [3H]histamine from synaptosomes of rat cer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Gliatech

Curated by ChEMBL
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine receptor H3(Dog)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  1.32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  5.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  12.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  51.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed