BDBM50368352 Cerubidine::DAUNORUBICIN

SMILES COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI Key InChIKey=STQGQHZAVUOBTE-UHFFFAOYSA-N

Data  5 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50368352   

Target72 kDa type IV collagenase(Human)
Technical University of Denmark

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 1.90E+3nMAssay Description:Concentration inhibiting Clostridium histolyticum collagenase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 8.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 2.36E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 1.39E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 2.36E+5nMAssay Description:Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 220nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 10nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  70nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  950nMAssay Description:TP_TRANSPORTER: inhibition of DNP-SG uptake in membrane vesicles from GLC4/ADR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  2.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  4.94E+4nMAssay Description:TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  1.11E+5nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed