BDBM7727 (3Z)-N-[(2,6-dimethoxyphenyl)methyl]-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazin-1-ylidene]-2,3-dihydro-1H-indole-5-carboxamide::3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dimethoxybenzyl)-2-oxo-5-indolinecarboxamide::CS247::Oxindole-Based Inhibitor 63

SMILES COc1cccc(OC)c1CNC(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)S(N)(=O)=O)c2c1

InChI Key InChIKey=VVJVXBGHOZRDRF-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7727   

LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataIC50: 9.30nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataIC50: 1.70nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataKd:  553nMpH: 7.5 T: 2°CAssay Description:ThermofluorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2012
Entry Details PubMed
TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataKd:  23nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2012
Entry Details PubMed
TargetCyclin-dependent kinase 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM7727(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-N-(2,6-dime...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed