BDBM8043 (4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-yl]amine::2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 14::CS13::N-(4-chlorophenyl)-4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine

SMILES Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(Cl)cc2)n1

InChI Key InChIKey=LZVYYWCYKXAVES-UHFFFAOYSA-N

Data  2 KI  5 Kd  2 Koff  2 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 8043   

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  965nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  1.19E+4nMpH: 7.5 T: 2°CAssay Description:ThermofluorMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  151nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  151nMAssay Description:OctetRed_Method2More data for this Ligand-Target Pair
In DepthDetails
D3R

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKoff:  2.09E+5s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails
D3R

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKon:  0.0200M-1s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails
D3R

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  965nMAssay Description:OctetRed_Method1More data for this Ligand-Target Pair
In DepthDetails
D3R

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKoff:  6.95E+4s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails
D3R

TargetCyclin-dependent kinase 2(Human)
Csar

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKon:  0.0394M-1s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails
D3R

LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  2.50E+3nM ΔG°:  -7.77kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.51kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed