BDBM82217 CHEMBL284994::CP-52003::SERTRALINE::[4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine

SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12

InChI Key InChIKey=VGKDLMBJGBXTGI-UHFFFAOYSA-N

Data  69 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 81 hits for monomerid = 82217   

TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 44nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 470nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 50nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT in rat corpus striatum by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 60nMAssay Description:Inhibition of [3H]dopamine reuptake at DAT in rat hypothalamus by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]norepinephrine reuptake at NET in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 60nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 10nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 44nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 20nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 270nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 39nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.0470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  78.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  159nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  188nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  232nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  315nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  380nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  427nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  477nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  714nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  817nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  925nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 81 total ) | Next | Last >>