BDBM50002134 5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)-1,3-benzodioxole-2,2-dicarboxylate::5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylate anion; disodium::5-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid;Disodium salt::CHEMBL32590::CL-316243::Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate::disodium 5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)-1,3-benzodioxole-2,2-dicarboxylate::disodium 5-[2-[2-(3-chlorophenyl)-2-hydroxyethylamino]-(2R)-propyl]benzo[d][1,3]dioxole-2,2-dicarboxylate(CL 316,243)

SMILES C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1

InChI Key InChIKey=JEDJMKTVUPSHFW-UHFFFAOYSA-L

Data  3 KI  4 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50002134   

TargetBeta-2 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataIC50: 2.70E+5nMAssay Description:Compound was evaluated for its binding affinity towards Beta-2 adrenergic receptor in rat soleus membrane by displacing (-)-isoproterenol (50 uM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  3nMAssay Description:In vitro beta adrenergic receptor activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol release from adip...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  2.62E+5nMAssay Description:Agonistic activity was assessed by measurement of cAMP accumulation levels in CHO cells expressing human beta-2-adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  1.15E+3nMAssay Description:Agonistic activity as cAMP accumulation in CHO cells expressing human beta-3-andrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  1.11E+5nMAssay Description:Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  25.1nMAssay Description:Agonistic activity towards beta-3 adrenoceptor. Mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataIC50: 9.77E+3nMAssay Description:Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50: >1.00E+6nMAssay Description:In vitro beta-adrenergic activity against beta-1 adrenergic receptor by stimulation of rate of contraction of guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataIC50: 1.30E+6nMAssay Description:Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataEC50:  220nMAssay Description:Agonist activity at Homo sapiens (human) beta3 adrenoreceptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataKi:  2.00E+4nMAssay Description:Compound was evaluated for its binding affinity to CHO cells expressing the cloned human Beta-3 adrenergic receptor in the presence of [125I]iodocyan...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataKi:  7.92E+4nMAssay Description:Inhibition of I-iodocyanopindolol binding to human beta 2 adrenergic receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50002134(CL-316243 | CHEMBL32590 | 5-{2-[2-(3-Chloro-phenyl...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of I-iodocyanopindolol binding to human beta 1 adrenergic receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed