BDBM50022279 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)-benzyl]-1-heptyl-urea::CHEMBL277986::CL-277082

SMILES CCCCCCCN(Cc1ccc(CC(C)(C)C)cc1)C(=O)Nc1ccc(F)cc1F

InChI Key InChIKey=QKJLDOBXDUVGEE-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50022279   

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 120nMAssay Description:In vitro inhibition of intestinal Acyl coenzyme A:cholesterol acyltransferase in cholesterol-fed rabbits.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibitory activity towards ACAT by the displacement of [1-14C]oleolyl-CoA from the small intestine of cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 740nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in intestinal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 320nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 3.20E+3nMAssay Description:In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 900nMAssay Description:Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 180nMAssay Description:Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 900nMAssay Description:Tested for inhibition against Acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate (>, denotes no effect at the concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 180nMAssay Description:Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of smooth muscle cell ACAT activity for cells stimulated by native LDL.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 6.06E+3nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in Aorta (homogenate Low-density lipoproteins (LDL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 810nMAssay Description:Inhibition of smooth muscle cell ACAT activity for cells stimulated by cationized LDL.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50022279(CL-277082 | 3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dime...)
Affinity DataIC50: 140nMAssay Description:Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in intestinal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed