BDBM50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=GUOQUXNJZHGPQF-UHFFFAOYSA-N

Data  65 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 50026756   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  0.810nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  39.6nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  46.3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  57nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  57nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  57nMAssay Description:Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  65nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  66nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  67.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  89.5nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  108nMAssay Description:Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  108nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  127nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  157nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  174nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  291nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  333nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
University Clinic For Psychiatry

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  405nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  447nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  460nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  560nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  561nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  561nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  561nMAssay Description:Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  620nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  644nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  720nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  780nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  850nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.15E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.16E+3nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.16E+3nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.16E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.31E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity for rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.62E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.74E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.79E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Universidad De Sevilla

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.84E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.96E+3nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.96E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  1.96E+3nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
UniversitÄT Heidelberg

Curated by PDSP Ki Database
LigandPNGBDBM50026756(CHEMBL13662 | CL 218872 | 3-Methyl-6-(3-trifluorom...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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