BDBM123129 1-(3-nitro-phenyl)-pyrrole-2,5-dione (17)::CID236790::US9182402, 1

SMILES [O-][N+](=O)c1cccc(c1)N1C(=O)C=CC1=O

InChI Key InChIKey=CJENYVWFVWQVPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 123129   

TargetGenome polyprotein(Hepacivirus C)
University of Wisconsin-Milwaukee

LigandPNGBDBM123129(CID236790 | 1-(3-nitro-phenyl)-pyrrole-2,5-dione (...)
Affinity DataIC50: 2.30E+4nMpH: 7.5 T: 2°CAssay Description:Binding assays containing 25 mM MOPS pH 7.5, 1.25 mM MgCl2, 20 nM Cy5-dT15, and 200 nM NS3h_1b were incubated 5 min at RT. Following addition of indi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM123129(CID236790 | 1-(3-nitro-phenyl)-pyrrole-2,5-dione (...)
Affinity DataIC50: 280nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetTrypsin(Pig)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM123129(CID236790 | 1-(3-nitro-phenyl)-pyrrole-2,5-dione (...)
Affinity DataIC50: 3.88E+3nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent