BDBM50005944 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide::CHEMBL22373::CI-976

SMILES CCCCCCCCCCC(C)(C)C(=O)Nc1c(cc(cc1OC)OC)OC

InChI Key InChIKey=WAFNZAURAWBNDZ-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50005944   

TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 110nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details
PDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Mouse)
Kowa

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 310nMAssay Description:Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 200nMAssay Description:Inhibition of ACAT activity in human MC65 cells using NBD-cholesterol staining after 48 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 73nMAssay Description:In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]oleolyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 149nMAssay Description:Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 73nMAssay Description:In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase, in intestinal microsomes isolated from cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 6.00E+3nMAssay Description:Concentration required for 50% inhibition of Acyl coenzyme A:cholesterol acyltransferase activity using microsomal ACAT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rabbit intestine microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Mouse)
Kowa

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 400nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 619nMAssay Description:Compound was tested for inhibitory activity against ACAT from U937 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 110nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 4.65E+3nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine adrenal glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 152nMAssay Description:Compound was tested for inhibitory activity against ACAT from rabbit intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 191nMAssay Description:Compound was tested for inhibitory activity against ACAT from rabbit liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 1.95E+3nMAssay Description:Compound was tested for inhibitory activity against ACAT from rabbit adrenal glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 4.59E+3nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 926nMAssay Description:Compound was tested for inhibitory activity against ACAT from HepG2 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 838nMAssay Description:Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Human)
Kansas State University

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50: 5.87E+3nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)