BDBM50034851 3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-propionylamino]-propionic acid::CGS-24592::CHEMBL285038::diphenyl alpha -aminomethyl phosphonate

SMILES OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O

InChI Key InChIKey=MVRLTBIHUWUGAR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034851   

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 2nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 0.810nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 1.60nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP 24.11) from rat kidney cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(CGS-24592 | diphenyl alpha -aminomethyl phosphonat...)
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article