BDBM50003776 8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid::CGS-22652::CHEMBL65414

SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1

InChI Key InChIKey=ISMHAZMNDUAHLK-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50003776   

TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 6nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 6nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane A2 receptor(Human)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 6nMAssay Description:Displacement of the high affinity radiolabeled ligand [3H]- SQ-29548 from the PGH-2/TXA-2 receptor in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of thromboxane synthetase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane A2 receptor(Human)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 18nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane-A synthase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThromboxane A2 receptor(Human)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50003776(CHEMBL65414 | CGS-22652 | 8-(4-Chloro-benzenesulfo...)
Affinity DataIC50: 18nMAssay Description:In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article