BDBM50004566 9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine::9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943)::9-Chloro-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943)::9-chloro-2-(2-furanyl)-1,2,4-triazolo[1.5-c]quinazolin-5-amine::9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine::CGS-15943::CHEMBL16687::CHEMBL268431::Nonnucleoside analog, 4
SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
InChI Key InChIKey=MSJODEOZODDVGW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 80 hits for monomerid = 50004566
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 8.48E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 406nMAssay Description:Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity for Adenosine A1 receptor from rat cerebral cortex membranes using [3H](R)-PIAMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Binding affinity towards the adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of 1 uM NECA-stimulated cyclic AMP levels in human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of binding towards adenosine A1 receptor using [3H]N-cyclohexyladenosine ([3H]CHA) in rat whole brain membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-1210...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of CK1epsilon (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 970nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of CK1alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Binding affinity against Q89D human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385 More data for this Ligand-Target Pair
Affinity DataKi: 0.350nM ΔG°: -12.9kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of rat recombinant adenosine receptor A2aMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Binding affinity against H278D human adenosine A2A receptor stably transfected in CHO cells using [3H]- ZM-241385 as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Displacement of [3H]-SCH- 58261 from human adenosine A2A receptor expressed in CHO cells; range 0.37-0.49More data for this Ligand-Target Pair
Affinity DataKi: 0.450nM ΔG°: -12.7kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (H250N) using [3H]-CGS-21,680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.520nMAssay Description:Binding affinity against H278E human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
Affinity DataKi: 0.670nMAssay Description:Binding affinity against T88E human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 5...More data for this Ligand-Target Pair
Affinity DataKi: 0.840nM ΔG°: -12.4kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
Affinity DataKi: 0.840nMAssay Description:Binding affinity for HA-tagged mutant human Adenosine A2A receptor (V84L), using [3H]CGS-21680 as radioligand expressed in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.840nMAssay Description:Binding affinity against WT human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Binding affinity against T88D human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
Affinity DataKi: 0.910nM ΔG°: -12.3kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
Affinity DataKi: 0.950nMAssay Description:Displacement of [3H]-CGS- 21680 from rat striatal membranes Adenosine A2A receptor. Parenthesis indicate 95% confidence limits.More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity against S277E human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]-CGS- from Adenosine A2a receptor of rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity for human Adenosine A2A receptor from HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.27nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in in human HeLa cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680More data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity towards adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Inhibition of rat recombinant adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells; range 4.1-4.7More data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Binding affinity for human Adenosine A1 receptor from HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6.40nMAssay Description:Binding ability of adenosine A1 receptor by using [3H]CHA as radioligand in rat whole brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 6.40nMAssay Description:Displacement of [3H]CHA from rat cortical membrane Adenosine A1 receptor. Parenthesis indicate 95% confidence limit.More data for this Ligand-Target Pair