BDBM50379186 CEP-11981::CHEMBL2010872

SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12

InChI Key InChIKey=AEULIVPVIDOLIN-UHFFFAOYSA-N

Data  2 KI  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50379186   

TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 50nMAssay Description:Inhibition of human Tie2 expressed in porcine PAE145 cells cotransfected with chimeric rat TRK-A/KDR receptor after 1 hr by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 132nMAssay Description:Inhibition of human ALK using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 42nMAssay Description:Inhibition of human Aurora-A using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 93nMAssay Description:Inhibition of human BTK using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 140nMAssay Description:Inhibition of human CHK2 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 48nMAssay Description:Inhibition of CK1 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 37nMAssay Description:Inhibition of human cSrc using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 13nMAssay Description:Inhibition of human FGFR1 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 89nMAssay Description:Inhibition of human FGFR3 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 3nMAssay Description:Inhibition of human VEGFR1 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 71nMAssay Description:Inhibition of human FLT3 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 78nMAssay Description:Inhibition of human FMS using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 21nMAssay Description:Inhibition of human MST2 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 246nMAssay Description:Inhibition of human PDGFRalpha using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 5nMAssay Description:Inhibition of human RET using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 14nMAssay Description:Inhibition of human TAK1 using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TRK-A using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 5nMAssay Description:Inhibition of human TRK-B using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Erg expressed CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Mouse)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse BLK using ATP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataKi:  500nMAssay Description:Inhibition of adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of muscarinic M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed