BDBM23174 6-chloro-1,2-benzoxazol-3-ol::6-chlorobenzo[d]isoxazol-3-ol::CBIO::CHEMBL445990

SMILES Clc1ccc2c(c1)o[nH]c2=O

InChI Key InChIKey=SJAPSPJRTQCDNO-UHFFFAOYSA-N

Data  6 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 23174   

TargetD-amino-acid oxidase(Pig)
Mgi Pharma

LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 188nMpH: 8.5 T: 2°CAssay Description:D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetD-aspartate oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human DDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 507nMAssay Description:Inhibition of human DAOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 17.2nMAssay Description:Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataKd:  14nMAssay Description:Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataKd:  13nMAssay Description:Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataKd:  18nMAssay Description:Binding affinity to human recombinant DAAO by steady state study scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-aspartate oxidase(Bovine)
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM23174(CHEMBL445990 | 6-chloro-1,2-benzoxazol-3-ol | 6-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed