BDBM50109811 (S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-piperidine-2-carboxylic acid 4-pyridin-3-yl-1-(3-pyridin-3-yl-propyl)-butyl ester::Biricodar::CHEMBL350775

SMILES COc1cc(cc(OC)c1OC)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCCc1cccnc1)CCCc1cccnc1

InChI Key InChIKey=CGVWPQOFHSAKRR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109811   

LigandPNGBDBM50109811((S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-p...)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of multidrug resistance associated protein type 1 (MRP1) assayed by an accumulation assay in COR.L23/R cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50109811((S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-p...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein (Pgp) using accumulation assay for Pgp expressing EMT6/AR1.0 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Max Planck Institute of Psychiatry

Curated by ChEMBL
LigandPNGBDBM50109811((S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-p...)
Affinity DataIC50: 17nMAssay Description:Binding affinity to FKBP12 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP5(Human)
Max Planck Institute of Psychiatry

Curated by ChEMBL
LigandPNGBDBM50109811((S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-p...)
Affinity DataIC50: 8.52E+3nMAssay Description:Binding affinity to FKBP51 FK1 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP4(Human)
Max Planck Institute of Psychiatry

Curated by ChEMBL
LigandPNGBDBM50109811((S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-p...)
Affinity DataIC50: 7.37E+3nMAssay Description:Binding affinity to FKBP52 FK1 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed