BDBM22722 1,2-diphenylethane-1,2-dione::Benzil::CHEMBL189886::Diphenylethane-1,2-dione

SMILES O=C(C(=O)c1ccccc1)c1ccccc1

InChI Key InChIKey=WURBFLDFSFBTLW-UHFFFAOYSA-N

Data  26 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 22722   

TargetFatty-acid amide hydrolase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant FAAH after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase(Pig)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 370nMAssay Description:Inhibition of pig liver carboxylesterase after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase(Pig)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 830nMAssay Description:Inhibition of pig liver carboxylesterase after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant FAAH after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human carboxylesterase 1 using o-nitrophenylacetate as substrate by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nMAssay Description:Inhibition constant against human intestinal carboxylesterase (hiCE) expressed in Sf21 cells using 3 mM o-NPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  15nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  15nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  15.1nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  44.7nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45nMAssay Description:Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45.1nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45.1nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45.1nMAssay Description:Inhibition constant against human liver carboxylesterase (hCE1) expressed in Sf21 cells using 3 mM o-NPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  45.1nMAssay Description:Inhibition constant against human liver carboxylesterase (hCE1) expressed in Sf21 cells using 3 mM o-NPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  103nMAssay Description:Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  103nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  148nM ΔG°:  -9.31kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  175nMAssay Description:Inhibition of human intestinal carboxylesterase assessed as hydrolysis of CPT-11 after 5 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of 1 mM acetylthiocholine (AcTCh) binding to human AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human butyrylcholinesterase using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed