BDBM50328639 (3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone::(3-chloro-4-fluorophenyl)(4-fluoro-4-(((5-methylpyridin-2-yl)methylamino)methyl)piperidin-1-yl)methanone::Befiradol::CHEMBL45305::US10562853, Compound Befiradol

SMILES Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1

InChI Key InChIKey=PKZXLMVXBZICTF-UHFFFAOYSA-N

Data  11 KI  2 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50328639   

Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataEC50:  26nMAssay Description:In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  0.400nMAssay Description:5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Rat)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  0.851nMAssay Description:Binding affinity to 5HT1A receptor in rat cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Rat)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  0.851nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-1A adrenergic receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi: >1.00E+3nMAssay Description:D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]Spiperone from human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 long receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Pig)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  2.30E+4nMAssay Description:Displacement of [3H]Ketanserin from 5-HT2 receptor in pig cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  2.60E+4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurolixis

US Patent
LigandPNGBDBM50328639((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Affinity DataKi:  4.60E+4nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 short receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed