BDBM50117901 2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide (BVT.14225)::BVT-14225::CHEMBL341324

SMILES CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1

InChI Key InChIKey=PNFMZAHWOASGJC-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50117901   

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 284nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration against human 11-beta-hydroxysteroid dehydrogenase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory concentration against human 11-beta-hydroxysteroid dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 284nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 52nMAssay Description:Displacement of [3H]cortisone from human 11beta-HSD1 expressed in baculovirus-infected Sf9 cells after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 28.4nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 284nMAssay Description:In vitro inhibitory activity against mouse 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 52nMAssay Description:In vitro inhibitory activity against human 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to convert [3H]cortisol to the tritium labeled cortisone in the presence of human 11 beta hydroxysteroid dehydrogenase type 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117901(2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thia...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human 11betaHSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed