BDBM50040348 8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-purine-2,6-dione::BRL-61063::CHEMBL356323

SMILES Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1

InChI Key InChIKey=KSPYMJJKQMWWNB-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50040348   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataEC50:  910nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataIC50: 7.10E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of adenosine binding to A1 receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040348(BRL-61063 | 8-Amino-1,3-bis-cyclopropylmethyl-3,7-...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of cGMP hydrolysis by PDE 5AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed