BDBM178100 BRD3308::US11377423, Cmpd 1
SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N
InChI Key InChIKey=RRJDFENBXIEAPD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 49 hits for monomerid = 178100
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human HDAC2 measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human recombinant HDAC1 at 0.1 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human HDAC1 measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human recombinant HDAC2 at 0.1 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human HDAC3 measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant HDAC3 at 0.5 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC2 expressed in Sf9 insect cells using FAM-labeled acetylated peptide A as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human full length C-terminal His/FALG-tagged HDAC1 expressed in Sf9 insect cells using FAM-labeled acetylated peptide A as ...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human full length HDAC3 using FAM-labeled acetylated peptide A as substrate preincubated for 3 hrs followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide substrate preincubated for 3 hrs by microfluidic capil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated peptide substrate preincubated for 3 hrs by microf...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of East Anglia
Curated by ChEMBL
University of East Anglia
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of His-tagged GST-fused human HDAC3/NcoR2 expressed in sf9 cells using carboxyfluorescein (FAM)-labeled acetylated peptide substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using carboxyfluorescein (FAM)-labeled acetylated peptide substrate by microflu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human HDAC5 using carboxyfluorescein (FAM)-labeled acetylated peptide substrate by microfluidic capillary electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide substrate by microfluidic capillary electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected sf9 cells using carboxyfluorescein (FAM)-labe...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 expressed in baculovirus infected sf9 cells using carboxyfluorescein (FAM)-labeled acetyl...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected sf9 cells using carboxyfluorescein (FAM)-lab...More data for this Ligand-Target Pair
Affinity DataKi: 29nM ΔG°: -10.3kcal/mole IC50: 64nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Binding affinity to human HDAC3 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 5.10E+3nM ΔG°: -7.21kcal/mole IC50: 1.08E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataKi: 5.10E+3nMAssay Description:Binding affinity to human HDAC1 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nMAssay Description:Binding affinity to human HDAC2 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nM ΔG°: -7.09kcal/mole IC50: 1.15E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair