BDBM178095 BRD2492

SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1ccncc1

InChI Key InChIKey=BBHURYMVPMFILR-UHFFFAOYSA-N

Data  6 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 178095   

TargetHistone deacetylase 4(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 3.33E+4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HDAC1 measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 19nMAssay Description:Inhibition of human HDAC2 measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of human HDAC3 measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nM ΔG°:  -11.6kcal/mole IC50: 2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nMAssay Description:Binding affinity to human HDAC1 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nM ΔG°:  -10.7kcal/mole IC50: 19nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nMAssay Description:Binding affinity to human HDAC2 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  1.40E+4nM ΔG°:  -6.62kcal/mole IC50: 2.08E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  1.40E+4nMAssay Description:Binding affinity to human HDAC3 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed