BDBM50138035 (biphenyl-4-yl)-aminomethylene-1,1-bisphosphonate::(biphenyl-4-ylamino)methylenediphosphonic acid::BPH-217::CHEMBL293479::[(Biphenyl-4-ylamino)-phosphono-methyl]-phosphonic acid

SMILES OP(O)(=O)C(Nc1ccc(cc1)-c1ccccc1)P(O)(O)=O

InChI Key InChIKey=BHTYFFISFVNOLJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50138035   

TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Diego

LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 4.60E+3nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 14(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 8.21E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 3.55E+5nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50138035((biphenyl-4-ylamino)methylenediphosphonic acid | (...)
Affinity DataIC50: 3.35E+4nMAssay Description:Inhibition of MMP14 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed